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001-es BibID:	BIBFORM010416
Első szerző:	Borbély Attila (kardiológus)
Cím:	Molecular determinants of heart failure with normal left ventricular ejection fraction / Borbely, A., Papp, Z., Edes, I., Paulus, W. J.
Dátum:	2009
ISSN:	1734-1140 (Print)
Megjegyzések:	In population-based studies, heart failure with normal left ventricular (LV) ejection fraction (HFNEF) is now increasingly recognized and referred to as diastolic heart failure. However, the pathogenic mechanisms underlying HFNEF are incompletely understood, mainly because of limited availability of human myocardial biopsy material. Nevertheless, recent studies have examined in vivo hemodynamics, in vitro cardiomyocyte function, myofilamentary protein composition, collagen content and deposition of advanced glycation end products from LV endomyocardial biopsies. These measures were compared between HFNEF patients, subjects without symptoms of heart failure (controls), patients with heart failure and reduced ejection function (HFREF), and patients with HFNEF and HFREF with diabetes mellitus. This article summarizes the various findings of these studies and focuses on the possible correlations among altered LV myocardial structure, cardiomyocyte function, myofilamentary proteins, and extracellular matrices. These findings revealed novel mechanisms responsible for diastolic LV dysfunction, and they have important therapeutic implications, particularly HFNEF, for which a specific heart failure treatment strategy is largely lacking.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Diabetes Complications Fibrosis Glycosylation End Products, Advanced Heart Failure, Diastolic Hemodynamics Humans Microfilaments Myocardium Myocytes, Cardiac Ventricular Dysfunction, Left Ventricular Function, Left
Megjelenés:	Pharmacological Reports. - 61 : 1 (2009), p. 139-145. -
További szerzők:	Papp Zoltán (1965-) (kardiológus, élettanász) Édes István (1952-) (kardiológus) Paulus, Walter J.
Internet cím:	elektronikus változat Intézményi repozitóriumban (DEA) tárolt változat
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