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001-es BibID:	BIBFORM013842
Első szerző:	Farkas Klaudia
Cím:	Red Blood Cell Distribution Width in Combination with Serological Markers can Help in the Differentiation between Crohn's Disease and Ulcerative Colitis / Klaudia Farkas, Mária Papp, Tibor Nyári, Ferenc Nagy, Zoltán Szepes, Tibor Wittmann, Tamás Molnár
Dátum:	2010
Megjegyzések:	Recent data suggest that red blood cell distribution width (RDW) could be a reliable marker indifferentiating Crohn's disease (CD) from ulcerative colitis (UC).Aim: Our study was to determine the sensitivity and specificity of RDW and serological markers for inflammatory boweldiseases (IBD), the risk for the diseases in case of abnormal RDW value and positive serological markersseparately and conjointly and to evaluate the efficacy of RDW in the differential diagnosis between IBD and irritablebowel syndrome (IBS). We also examined the influence of the drug treatments on the alteration of RDW values.Patients and methods: The clinical records of 98 CD, 81 UC, 26 IBS patients and 84 healthy controls were reviewed.Sensitivity, specificity and relative risk of RDW and ASCA IgA, ASCA IgG and anti-OmpC antibodies for CD and UCwere assessed. RDW values of IBS patients and IBD patients were also statistically compared.Results: RDW was significantly elevated in IBD patients compared to IBS patients. 92% specificity cutpoint at a RDWlevel of 13.4% was detected in both CD and UC independently of the disease activity. Significantly higher risk forCD was observed in case of combined assessment of abnormal RDW and positive ASCA IgA vs. the other serologicalmarkers or to separate determination of RDW.Conclusion: RDW could be a useful and inexpensive activity marker, which may help in the differential diagnosisbetween IBD and IBS and using in combination with ASCA IgA it shows a synergistic effect in the distinction of CDfrom UC.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Red blood cell distribution width Crohn's disease Open Access ulcerative colitis egyetemen (Magyarországon) készült közlemény
Megjelenés:	The Open Gastroenterology Journal. - 4 (2010), p. 1-4. -
További szerzők:	Papp Mária (1975-) (belgyógyász, gasztroenterológus) Nyári Tibor Nagy Ferenc (orvos Szeged) Szepes Zoltán Wittmann Tibor Molnár Tamás (orvos Szeged)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat Szerző által megadott URL
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