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001-es BibID:BIBFORM015611
035-os BibID:11451408
Első szerző:Felszeghy Szabolcs Béla (fogorvos, anatómus, kötőszövetbiológus)
Cím:The distribution pattern of the hyaluronan receptor CD44 during human toothdevelopment / Szabolcs Felszeghy, László Módis, Markku Tammi, Raija Tammi
Dátum:2001
ISSN:0003-9969 (Linking)
Megjegyzések:The aim was to investigate the expression pattern of the major cell-surfacehyaluronan receptor CD44, as there are no existing data on its presence orabsence in human dental structures at different developmental stages.Immunohistochemical localization of CD44 was studied using a monoclonal antibody,H3, that specifically recognizes an epitope in the common backbone of all CD44isoforms. The dental lamina displayed a strong CD44 signal; the external enamelepithelium was negative. In the coronal region of the tooth germ the presecretoryameloblasts showed an intense reaction whereas the less differentiated innerenamel epithelial cells showed no signal at the cervical loop where they meet theexternal enamel epithelium. In the stellate reticulum a moderate reaction wasdetected. The secretory ameloblasts and the stratum intermedium showed a strongcell-surface CD44 signal. A strong signal was also observed on the odontoblastsand their processes. In the pulp, close to the odontoblastic layer, weaklabelling was seen in the walls of capillary vessels. The distribution of CD44 inthe human tooth germ corresponds to that of hyaluronan in most locations,suggesting that during tooth development this transmembrane protein plays animportant part in hyaluronan-mediated events.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
0 (Antibodies, Monoclonal)
0 (Antigens, CD44)
Age Factors
Ameloblasts/chemistry/metabolism
Antibodies, Monoclonal
Antigens, CD44/*analysis/biosynthesis
Embryonic and Fetal Development
Humans
Immunohistochemistry
Infant
Infant, Newborn
Odontoblasts/chemistry/metabolism
Tooth Germ/*chemistry/metabolism
egyetemen (Magyarországon) készült közlemény
Megjelenés:Archives of Oral biology. - 46 : 10 (2001), p. 939-945. -
További szerzők:Módis László (1939-) (anatómus, kötőszövetbiológus) Tammi, Markku (kutatóorvos) Tammi, Raija (kutatóorvos)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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