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001-es BibID:	BIBFORM015779
Első szerző:	Opposits Gábor (fizikus, szoftver fejlesztő)
Cím:	Complex software framework for tracer kinetic analysis of receptor ligand binding / G. Opposits, A. S. Kis, P. Mikecz, L. Balkay, L. Trón, M. Emri
Dátum:	2009
Megjegyzések:	Human and small animal PET receptor studies belong to the most important in vivo tools of pharmaceutical research. Tracer kinetic analysis and digital brain atlas methods belong to the commonly used techniques to process images obtained by dynamic scanning. Regional analysis can be done either on the basis of individually drawn brain regions or using regional databases of human-, mouse- and rat brain atlases. The aim of the study was to work out validated, complex software framework supporting the effective processing of multi-subject binding experiments and modelcalculations. Results: The Image Sorter is the first element of the software framework which converts the format of the images arriving at the DICOM server of the institute to MINC (a useful working format) and carries out each task in an executable automated manner. Generation of summation images, MRI-PET registration and spatial standardization belong to the latter type of tasks. BrainTrace, a multimodal, interactive image processing software have been developed for the interactive work up of images produced by the Image Sorter. The verification and the eventually necessary correction of MRI-PET registration can be done by BrainTrace. The same program can support the manual or brain atlas based drawing of regions required by the tracer kinetic analysis as well as the evaluation of the parametric images. BrainTrace's components responsible for model calculations were validated by PVELab a Matlab based tracer kinetic software. Conclusion: The developed software framework containing automated and interactive elements allows the routine work up of dynamical binding examinations carried out using PET ligands.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:	Nuclear Medicine Review. - 12 : 1 (2009), p. 47. -
További szerzők:	Kis Sándor Attila (1973-) (fizikus) Mikecz Pál (1956-) (vegyész) Balkay László (1963-) (biofizikus) Trón Lajos (1941-) (biofizikus) Emri Miklós (1962-) (fizikus)
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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