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001-es BibID:	BIBFORM015870
Első szerző:	Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:	Angiogenesis and vasculogenesis in rheumatoid arthritis / Szekanecz, Z., Besenyei, T., Szentpetery, A., Koch, A. E.
Dátum:	2010
ISSN:	1531-6963 (Electronic)
Megjegyzések:	Angiogenesis is the formation of new capillaries from pre-existing vessels, whereas vasculogenesis is de-novo capillary formation from endothelial precursor cells (EPCs). Current understanding of the role of angiogenesis and vasculogenesis in rheumatoid arthritis (RA) and possibilities of therapeutic intervention should be summarized. RECENT FINDINGS: There have been many recent studies on the role of the hypoxia and hypoxia-inducible factor (HIF)-vascular endothelial growth factor (VEGF)-angiopoietin axis in angiogenesis associated with RA. The role of additional growth factors, chemokines, cytokines, matrix components and adhesion molecules has been further characterized. Macrophage migration inhibitory factor (MIF) may link inflammation, angiogenesis and atherosclerosis. Junctional adhesion molecules (JAMs) and focal adhesion kinases (FAKs) have recently been implicated in inflammatory angiogenesis. Novel information regarding the role of serum amyloid A (SAA) and sphingosine kinase has become available. Most of these angiogenic factors have recently been targeted using various techniques and arthritis models. Whereas angiogenesis is abundant in RA, there is defective EPC function and vasculogenesis leading to atherosclerosis and vascular disease in arthritis. Treatment with EPCs already under investigation in vascular diseases may also be attempted in RA. SUMMARY: Targeting angiogenesis and restoration of vasculogenesis may be beneficial for the therapy and outcome of RA.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Angiogenesis Inhibitors/pharmacology/therapeutic use Angiogenic Proteins/antagonists & inhibitors/metabolism Arthritis/complications/metabolism/physiopathology Arthritis, Rheumatoid/complications/metabolism/physiopathology Blood Vessels/drug effects/metabolism/physiopathology Endothelial Cells/drug effects/immunology/metabolism Humans Neovascularization, Pathologic/drug therapy/immunology/physiopathology Vascular Diseases/drug therapy/immunology/physiopathology
Megjelenés:	Current Opinion in Rheumatology. - 22 : 3 (2010), p. 299-306. -
További szerzők:	Besenyei Tímea (1980-) (reumatológus, belgyógyász) Szentpétery Ágnes (1978-) (reumatológus) Koch, Alisa E.
Internet cím:	DOI elektronikus változat Intézményi repozitóriumban (DEA) tárolt változat
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