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001-es BibID:BIBFORM016485
Első szerző:Sanna, Daniele (vegyész)
Cím:A quantitative study of the biotransformation of insulin-enhancing VO2+ compounds / Daniele Sanna, Péter Buglyó, Giovanni Micera, Eugenio Garribba
Dátum:2010
ISSN:0949-8257
Megjegyzések:Potentiometric (pH titrations) and spectroscopic (electron paramagnetic resonance) methods have been used to determine the thermodynamic stability constants of the various VO2+ complexes formed after the interaction of four insulin-enhancing vanadium compounds, [VO(6-mepic)(2)], cis-[VO(pic)(2)(H2O)], [VO(acac)(2)], and [VO(dhp)(2)], where 6-mepic, pic, acac, and dhp indicate the deprotonated forms of 6-methylpicolinic acid, picolinic acid, acetylacetone, and 1,2-dimethyl-3-hydroxy-4(1H)-pyridinone, with high molecular mass [human serum apotransferrin (hTf) and human serum albumin (HSA)] and low molecular mass (lactate) components of blood serum. In particular, log beta values for the formation of (VO)hTf (13.0 +/- A 0.5), (VO)(2)hTf (25.5 +/- A 0.5), (VO)HSA (9.1 +/- A 1.0), (VO) (2) (d) HSA (20.9 +/- A 1.0), cis-VO(dhp)(2)(hTf) (25.5 +/- A 0.6), cis-VO(dhp)(2)(HSA) (25.9 +/- A 0.6), (VO)hTf(lact) (14.5 +/- A 0.8), (VO)(2)hTf(lact)(2) (28.5 +/- A 0.8), (VO)hTf(pic) (15.6 +/- A 0.8), and (VO)(2)hTf(pic)(2) (30.4 +/- A 0.8) were determined. The values of the stability constants were used to compare the calculated composition of ternary and quinary systems with that recently proposed by some of us through electron paramagnetic resonance and density functional theory methods (Sanna et al. in Inorg. Chem. 49:174-187, 2010) and to predict the distribution of VO2+ ion in blood serum when one of the four insulin-enhancing vanadium compounds studied, [VO(carrier)(2)], is administered.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Vanadium
Insulin-enhancing drugs
Stability constants
Transport in
blood serum
electron-paramagnetic-resonance
alpha-hydroxycarboxylic acids
blood-serum
oxovanadium(iv) complexes
human serotransferrin
in-vitro
dissociation-constants
glucose-metabolism
structural-changes
vanadium compounds
Megjelenés:Journal of Biological Inorganic Chemistry. - 15 : 6 (2010), p. 825-839. -
További szerzők:Buglyó Péter (1965-) (vegyész) Micera, Giovanni Garribba, Eugenio
Internet cím:DOI
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