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001-es BibID:BIBFORM016926
035-os BibID:(WoS)000166385500013 (Scopus)0035165276
Első szerző:Sulyok Endre
Cím:Brain water and proton magnetic resonance relaxation in preterm and term rabbit pups : their relation to tissue hyaluronan / Sulyok E., Nyúl Z., Bogner P., Berényi E., Repa I., Vajda Z., Dóczi T., Sedin G.
Dátum:2001
ISSN:0006-3126
Megjegyzések:The present study was performed to investigate simultaneously totalbrain water, T1 and T2 relaxation times, and hyaluronan (HA) in fetaland neonatal rabbits. Attempts were also made to establish therelationship of HA to total brain water and to T2-derived motionallydistinct water fractions, since HA is known to bind water and to limittissue water mobility. Experiments were carried out in fetal Pannonwhite rabbit pups at gestational ages of 25, 27, 29, and 31 days and ata postnatal age of 4 days. The brain tissue water content (desiccationmethod), T1 and T2 relaxation times (H-1-NMR method), and HAconcentration (radioassay HA 50) were measured, and free and boundwater fractions were calculated by using multicomponent fits of the T2relaxation curves. Compared with values in newborn pups, water and HAcontents were found to be highly elevated in the preterm brain anddecreased markedly during early postnatal life. The trends and timecourses of T1 and T2 relaxation times proved to be similar, but thepostnatal decrease in T2 was preceded by a significant decline in lategestation. Maturity-related changes occurred in the T2 relaxationderived bound water fraction which amounted to 4-19% of brain water.The bound water fraction appeared to be independent of total brainwater and HA concentration, and HA is, therefore, unlikely to be theonly factor controlling brain water mobility. The clear dissociation ofbound water fraction from total water suggests restructuring of brainwater during the perinatal period.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Biology of the Neonate. - 79 : 1 (2001), p. 67-72. -
További szerzők:Nyúl Zoltán Bogner Péter (1963-) (radiológus) Berényi Ervin (1964-) (radiológus) Repa Imre (1950-) (radiológus) Vajda Zsolt Dóczi Tamás Sedin, Gunna
Internet cím:DOI
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