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001-es BibID:BIBFORM016927
035-os BibID:(WoS)000089532600022 (Scopus)0033799578
Első szerző:Sedin, Gunna
Cím:Lung water and proton magnetic resonance relaxation in preterm and termrabbit pups : their relation to tissue hyaluronan / Sedin G., Bogner P., Berényi E., Repa I., Nyúl Z., Sulyok E.
Dátum:2000
ISSN:0031-3998
Megjegyzések:The present study was performed to investigate simultaneously totallung water, T-1 and T-2 relaxation times, and hyaluronan (HA) inpreterm and term rabbits. Attempts were also made to establish therelationship of HA to total lung water and to T-2-derived motionallydistinct water fractions. Experiments were performed in fetal Pannonwhite rabbit pups at gestational ages of 25, 27, 29, and 31 d and at apostnatal age of 4 d. Lung tissue water content (desiccation method),T-1 and T-2 relaxation times (H-1-NMR method), and HA concentration(radioassay) were measured, and free and bound water fractions werecalculated by using multicomponent fits of the T-2 relaxation curves.Lung water content and T-1 and T-2 relaxation times were highest at agestational age of 27 d and then declined steadily during the wholestudy period. Similar trends and time courses were seen for the fastand slow components of the T-2 relaxation curve. The T-2-derived freewater fraction remained unchanged at a gestational age of 25-29 d(similar to 67%), but increased progressively to a value of 78.5 +/-7.9% at 31 d (p < 0.001) and to 83.4 +/- 9.4% at the postnatal age of 4d (p < 0.01), Opposite changes occurred in the bound water fraction.Lung HA concentration decreased with advancing gestation from 870.8 +/-205.2 mu g/g dry weight at 25 d to 162.6 +/- 32.4 mu g/g dry weight at31 d (p < 0.001), but it was increased 2-fold postnatally, EIAcorrelated positively with total lung water (r = 0.39; p < 0.001) butnot with the bound water fraction. It is suggested that the physiologiclung dehydration is associated with macromolecule-relatedreorganization of lung water and that the role of IIA in this processneeds to be further investigated.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Pediatric Research. - 48 : 4 (2000), p. 554-559. -
További szerzők:Bogner Péter (1963-) (radiológus) Berényi Ervin (1964-) (radiológus) Repa Imre (1950-) (radiológus) Nyúl Zoltán Sulyok Endre
Internet cím:DOI
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