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001-es BibID:	BIBFORM016932
035-os BibID:	(WoS)A1996UN55500026 (Scopus)0029943452
Első szerző:	Berényi Ervin (radiológus)
Cím:	Postnatal changes in water content and proton magnetic resonance relaxation times in newborn rabbit tissues / Berényi E., Szendrö Z., Rózsahegyi P., Bogner P., Sulyok E.
Dátum:	1996
ISSN:	0031-3998
Megjegyzések:	In the present study, using proton nuclear magnetic resonancerelaxation (H-1 NMR) measurements, an attempt was made to quantitatewater fractions with different mobility in the skin, skeletal muscle,and liver tissues obtained from New Zealand white rabbit pups. Serialstudies were carried out at the postnatal age of 0-1, 24, 48, and 72 hin pups nursed with their mothers and suckling ad libitum (group I) andin those pups separated from their mothers and completely withheld fromsuckling (group II). Tissue water content (desiccation method) and T-1and T-2 relaxation times (H-1 NMR method) were measured. Free. looselybound, and tightly bound water fractions were calculated by applyingmulticomponent fits of the T-2 relaxation curves. It was demonstratedthat skin water content and T-1 and T-2 relaxation times decreased withage (p < 0.01), the decrease in T-2 proved to be more pronounced ingroup II than in group I (p < 0.05). Muscle and liver water, and T-1and T-2 relaxation times did not change with age in the suckling pups.In response to withholding fluid intake muscle water remained constant,liver water increased paradoxically (p < 0.05), T-1 relaxation timeshowed no consistent change in either tissues, whereas T-2 relaxationtime decreased significantly (muscle, p < 0.01) or tended to decrease(liver, p < 0.06). Using biexponential analysis fast and slowcomponents of T-2 relaxation curve could be distinguished thataccounted for 42-47%, 50-57%, and 34-40% of total tissue water in theskin, skeletal muscle, and liver, respectively, regardless of age andfluid intake. Triexponential fits of the T-2 relaxation curve madepossible the further partition of tissue water into tightly bound (fastcomponent), loosely bound (middle component), and free (slow component)water fractions. In all tissues studied, loosely bound fractionpredominated (skin, 48-64%; muscle, 54-65%; liver, 45-63%), followed bythe free (skin, 26-45%; muscle, 23-32%; liver, 20-25%) and the tightlybound water fraction (skin, 6-14%; muscle, 10-16%; liver, 14-33%).Postnatal age and fluid intake had no apparent influence on thispattern of distribution. It is concluded that the majority of neonataltissue water is motion-constrained. The free, the loosely bound, andthe tightly bound water fractions appear to be interrelated anddependent on age, fluid intake, the tissues studied, and theirhydration.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Pediatric Research. - 39 : 6 (1996), p. 1091-1098. -
További szerzők:	Szendrö Z. Rózsahegyi P. Bogner Péter (1963-) (radiológus) Sulyok Endre
Internet cím:	DOI
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