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001-es BibID:	BIBFORM017338
Első szerző:	Nagy T. József (belgyógyász)
Cím:	Activition of the lipoxygenase pathway in the methionine enkephalin induced respiratory burst in human polymorphonuclear leukocytes / J. T. Nagy, G. Fóris, T. Fülöp Jr., G. Paragh, N. P. Plotnikoff
Dátum:	1988
ISSN:	0024-3205
Megjegyzések:	In comparative studies of f-met-Leu-Phe (FMLP) and methionine enkephalin (ME) induced polymorphonuclear leukocyte (PMNL) stimulation the following results were obtained: (i) both FMLP and ME increased the intracellular killing (IK) capability of human PMNLs probably through NADPH oxidase activation, (ii) the ME-induced respiratory burst (RB) differed from the chemotactic peptide FMLP-triggered superoxide generation because the former was not accompanied by the activation of the glutathione system and the duration of the superoxide production was prolonged. The reaction was dependent on lipoxygenation, was potentiated by indomethacin (IM) and was inhibited by nordihidro-guairetic acid (NDGA), (iii) both 14C-arachidonic acid (14C-AA) release and leukotriene B4 (LTB4) synthesis of ME-treated PMNLs were elevated as compared to those of FMLP triggered cells. Our results suggest that lipoxygenation and even an increased LTB4 synthesis are involved in the ME-induced RB of leukocytes
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Life Sciences. - 42 : 22 (1988), p. 2299-2306. -
További szerzők:	Fóris Gabriella (1937-) (belgyógyász) Fülöp Tamás Jr Paragh György (1953-) (belgyógyász) Plotnikoff, N. P.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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