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001-es BibID:	BIBFORM018442
Első szerző:	Bagi Zsolt (orvos)
Cím:	Microvascular responsiveness in obesity : implications for therapeutic intervention / Zsolt Bagi, Attila Feher, James Cassuto
Dátum:	2012
ISSN:	0007-1188
Megjegyzések:	Obesity has detrimental effects on the microcirculation. Functional changes in microvascular responsiveness may increase the risk of developing cardiovascular complications in obese patients. Emerging evidence indicates that selective therapeutic targeting of the microvessels may prevent life-threatening obesity-related vascular complications, such as ischemic heart disease, heart failure and hypertension. It is also plausible that alterations in adipose tissue microcirculation contribute to the development of obesity. Therefore, targeting adipose tissue arterioles could represent a novel approach to reducing obesity. This review aims to examine recent studies that have been focused on vasomotor dysfunction of resistance arteries in obese humans and animal models of obesity. Particularly, findings in coronary resistance arteries are contrasted to those obtained in other vascular beds. We provide examples of therapeutic attempts, such as use of statins, angiotensin converting enzyme inhibitors and insulin sensitizers to prevent obesity-related microvascular complications. We further identify some of the important challenges and opportunities going forward.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban obesity microcirculation arteriole coronary type 2 diabetes mellitus
Megjelenés:	British Journal Of Pharmacology. - 165 : 3 (2012), p. 544-560. -
További szerzők:	Fehér Attila (1982-) (orvos) Cassuto, James
Pályázati támogatás:	R01 HL104126 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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