Találati lista | Tudóstér

001-es BibID:	BIBFORM018698
Első szerző:	Enyedy Éva Anna (vegyész)
Cím:	Interaction of folic acid and some matrix metalloproteinase (MMP) inhibitor folate-[gamma]-hydroxamate derivatives with Zn(II) and human serum albumin / Éva A. Enyedy, Etelka Farkas, Orsolya Dömötör, M. Amélia Santos
Dátum:	2011
ISSN:	0162-0134
Megjegyzések:	Human serum albumin binding of folic acid and its [gamma]-hydroxamate/carboxylate derivatives was studied byultrafiltration and spectrofluorimetry, and it was found that the ligands exhibit a moderate binding (KD ~2?50 ?M), and the folate-[gamma]-phenylalanine represents the highest conditional binding constant towards albumin.This feature may have importance in the serum transport processes of these ligands. Interaction of folic acidand its derivatives with Zn(II) was investigated in aqueous solution to obtain the composition and stabilitiesof the complexes by the means of pH-potentiometry, 1H NMR and electrospray ionization mass spectrometry,together with the characterization of the proton dissociation processes and the hydro-lipophilic properties ofthe ligands. The formation of mono-ligand complexes was demonstrated in all cases and the contribution ofthe glutamyl carboxylates to the coordination was excluded. Binding of folic acid and its [gamma]-carboxylatederivatives to Zn(II) via the pteridine moiety is suggested, while the (O,O) coordination fashion of the folate-[gamma]-hydroxamate ligands has importance in their inhibitory activity against Zn(II)-containing matrixmetalloproteinases. It was found that the enzyme inhibition of these folate-[gamma]-hydroxamate ligands is mainlytuned by other features, such as the lipophilic character rather than the Zn(II)-chelate stability.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Molekulatudomány Solution equilibrium Stability constants Folic acid Folate-[gamma]-hydroxamate conjugates Protein-[gamma]-ligand interaction Ultrafiltration
Megjelenés:	Journal Of Inorganic Biochemistry. - 105 : 3 (2011), p. 444-453. -
További szerzők:	Farkas Etelka (1948-) (vegyész) Dömötör Orsolya Santos, Amélia M.
Pályázati támogatás:	TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP Fémionok és biológiailag aktív hidroxámsavak kölcsönhatása
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: