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001-es BibID:	BIBFORM020101
Első szerző:	Görlach, Christoph
Cím:	Neuronal nitric oxide synthase inhibitor has a neuroprotective effect in a rat model of brain injury / Christoph Görlach, Tibor Hortobágyi, Szabolcs Hortobágyi, Zoltán Benyó
Dátum:	2000
Megjegyzések:	Purpose: The aim of the present study was to assess the effects of neuronal nitric oxide synthase (NOS I) inhibitors and a combination of NOS I and NOS II inhibitors on lesion volume after experimental brain injury. Methods: Cold lesion of the brain was induced by application of a precooled (-78 degrees C) copper cylinder to the intact dura of the rat for 6 s. Brains were removed 24 h after the injury and lesion volume determined using the triphenyltetrazolium-chloride method. Results: The specific NOS I inhibitor 3-bromo-7-nitroindazole (Br-7-NI) reduced lesion volume significantly by 21 % compared with the vehicle control. In contrast, 7-nitroindazole had no effect on lesion volume. When aminoguanidine, a specific NOS II inhibitor, was adminis-tered after Br-7-NI, lesion volume was significantly reduced but not significantly more than with either compound alone. Conclusion: Brain injury after cold lesion is partly mediated by NOS I activity and can be attenuated successfully with Br-7-NI, while coin-hibition of NOS II does not improve the outcome significantly.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Restorative Neurology and Neuroscience. - 17 : 2-3 (2000), p. 71-76. -
További szerzők:	Hortobágyi Tibor (1965-) (patológus) Hortobágyi Szabolcs Benyó Zoltán
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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