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001-es BibID:	BIBFORM022341
035-os BibID:	(dekdb)bibDEK00730919
Első szerző:	Bánfalvi Gáspár (sejtbiológus, gyógyszerész)
Cím:	Apoptotic chromatin changes / Bánfalvi Gáspár
Dátum:	2011
Megjelenés:	Dordrecht : Springer, 2009
Terjedelem:	412 p.
Megjegyzések:	The writing of this book is based on: 1. earlier experience writing textbooks for biology students with a university-level background in biology and biochemistry with many (> 200) figures in these books (in Hungarian), 2. and on the necessity to present university lectures as power point presentations to catch the interest of students. The author realizes that young readers who were grown up in an information society are relactant to read too much unless they have to take exams. Even than they prefer books which contain illustrations for a better understanding. In collaboration with colleagues, referees and members of the publishing staff an extensive set of photographs and illustrations were collected to provide a graphic follow-up to the text. Further aids for the student, instructor and the curious reader are provided by summaries, extensive sets of readings and references for each chapter, a glossary of the terms, list of abbreviations and a DVD with a red-blue eyeglass to visualize three dimensional chromatin structures.The reader could ask: Why another book on apoptosis? The answer to the question is related to the definition of the process. The term apoptosis has been introduced to describe typical morphological changes leading to controlled self-destruction of cells. The first demonstrated biochemical feature of this type of cell death was internucleosomal fragmentation, which was occasionally preceded by the generation of large DNA fragments. It turned out that cytoplasmic changes may take place in cells lacking nuclei, indicating that apoptosis may occur without endonuclease mediated DNA degradation while reproducible proteolytic cleavage was observed, pointing to the importance of proteases in the induction and completion of apoptotic cell death. However, the most typical large-scale morphological changes of apoptosis at the chromatin level could not be visualized so far. The book contains reproducible fluorescent chromatin structures some of them subjected to Computer Image Analysis (CIA method) to visualize not only large-scale chromatin changes but also those structures which were invisible for the human eye, but traceable with the aid of a computer. As apoptosis has been extensively reviewed in several other books this book will discuss primarily the morphological aspects of apoptosis. Chapter I will focus on the evolutionary aspects of the genetic material, Chapter II deals with the structure of DNA, Chapter III is devoted to chromatin structure, Chapter IV to apoptotic chromatin changes in healthy cells and Chapter V to genotoxic chromatin changes.
ISBN:	978-1-4020-9560-3 978-1-4020-9561-0 (e-ISBN)
Tárgyszavak:	Természettudományok Biológiai tudományok monográfia kromatin szerkezet
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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