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001-es BibID:	BIBFORM023665
Első szerző:	Raivio, Tiina
Cím:	Self transglutaminase-based rapid coeliac disease antibody detection by a lateral flow method / T. Raivio, K. Kaukinen, E. Nemes, K. Laurila, P. Collin, J. B. Kovács, M. Mäki, I. R. Korponay-Szabó
Dátum:	2006
Megjegyzések:	The conventional coeliac disease antibody tests require patient's sera, and are laborious and time-consuming. AIM: To evaluate a newly developed rapid whole blood test in coeliac disease antibody detection, and its suitability for office use. METHODS: Endogenous tissue transglutaminase found in red blood cells in a whole blood fingertip or venous sample is liberated upon haemolysis and complexes with tissue transglutaminase antibodies, if present. The complexes, captured by a lateral flow system, are visualized within 5 min. Stored samples from 121 untreated, 106 treated coeliac disease patients and 107 controls were evaluated and compared with serum endomysium and tissue transglutaminase antibody tests and histology; 150 patients were prospectively tested on site in the doctor's office. RESULTS: The rapid test showed sensitivity (96.7%) comparable with the serum endomysium and tissue transglutaminase antibody tests from stored samples; specificity was slightly lower (93.5%). When tested on site the results were concordant in 96.7% of cases compared with endomysium and tissue transglutaminase antibody results. The test recognized the disappearance of tissue transglutaminase antibodies on a gluten-free diet. CONCLUSIONS: The self tissue transglutaminase-based rapid test can be easily carried out from a fingertip blood sample on site in the physician's office for both coeliac disease case finding and dietary monitoring purposes.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Alimentary Pharmacology & Therapeutics. - 24 : 1 (2006), p. 147-154. -
További szerzők:	Kaukinen, Katri Nemes Éva (1957-) (csecsemő- és gyermekgyógyász, gasztroenterológus) Laurila, Kaija Collin, P. B. Kovács Judit Mäki, Markku Korponay-Szabó Ilma (1959-) (gyermekgyógyász)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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