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001-es BibID:	BIBFORM024107
Első szerző:	Szabó Gábor (biofizikus)
Cím:	Specific Disengagement of Cell-Bound Anti-Lam-1 (Anti-L-Selectin) Antibodies by Aurintricarboxylic Acid / Gábor Szabo Jr., James L. Weaver, P. Scott Pine, Adorján Aszalos
Dátum:	1993
Megjegyzések:	Brief treatment of human peripheral blood lymphocytes with the potential anti-HIV compound aurintricarboxylic acid (ATA) prompts the selective release of already bound L-selectin-specific anti-leu8 and anti-LAM1-1 antibodies from the cells. Two other anti-LAM1 antibodies, anti-LAM1-3 and anti-LAM1-5 stay antigen-bound at the same time. interestingly, the ATA-sensitive anti-leu8 strongly competes with the ATA-resistant anti-LAM1-3 for binding. Photobleaching fluorescence resonance energy transfer (pFRET) measurements on flow-sorted cells suggests that these two antibodies compete for the same epitope, while anti-LAM1-5-FITC and anti-Leu8-PE bind to distinct sites, although they also compete for binding. Combining the data on competition, pFRET and ATA effect, we suggest that the ATA sensitive anti-leu8 and resistant anti-LAM1-3 bind to overlapping but non-identical epitopes. This remarkably specific effect may be exploited for designing anti-inflammatory drugs that modulate leukocyte adhesion
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Antibodies blood Cells Energy Transfer Epitopes Fluorescence Fluorescence Resonance Energy Transfer Human lymphocyte Lymphocytes Photobleaching time
Megjelenés:	Molecular Immunology. - 30 : 18 (1993), p. 1689-1694. -
További szerzők:	Weaver, James L. Pine, P. Scott Aszalos Adorján
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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