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001-es BibID:	BIBFORM024352
Első szerző:	Barkai László (gyermekgyógyász)
Cím:	Association of angiotensin-converting enzyme DD genotype with 24-h blood pressure abnormalities in normoalbuminuric children and adolescents with Type 1 diabetes / L. Barkai, A. Soós, I. Vámosi
Dátum:	2005
Megjegyzések:	Aims: To assess the distribution of the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene in children and adolescents with Type 1 diabetes and to evaluate the association between ACE genotype and blood pressure (BP). Methods: ACE genotypes were assessed in 124 normoalbuminuric, clinically normotensive Type 1 diabetic children and adolescents and 120 non-diabetic controls using polymerase chain reaction. Twenty-four-hour ambulatory BP monitoring was undertaken in all patients. Results: ACE genotypes distributed in patients as follows: 34 (27%) DD, 57 (46%) ID, 33 (27%) II. The distribution was similar in the control group: DD in 28% (33), ID in 45% (54), and II in 27% (33). Patients with DD genotype had higher mean 24-h diastolic BP (73.8 ? 6.2 vs. 70.2 ? 5.0 and 69.7? 6.3 mmHg; P = 0.005) and lower diurnal variation in BP (11.8 ? 4.6 vs. 14.2 ? 4.2 and 14.8 ? 4.3%; P = 0.011) compared with ID and II groups. Four patients in the DD group proved to be non-dipper compared with one in the ID and none in the II group (P = 0.026). Twenty-four-hour diastolic blood pressure was independently predictive for AER as dependent variable in the DD genotype patient group (r<sup>2</sup> = 0.12, P = 0.03). Conclusions: Children and adolescents with Type 1 diabetes do not differ from the non-diabetic population regarding the I/D polymorphism of the ACE gene. ACE gene polymorphism is associated with BP abnormalities in normotensive and normoalbuminuric children and adolescents with Type 1 diabetes. ? 2005 Diabetes UK. PubMed ID: 16026372 UR: http://www.scopus.com/inward/record.url?eid=2-s2.0-22644435103&partnerID=40&md5=b194d518803646e997d3ce35e7e2f22d http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-22644435103
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Sequence Deletion Polymorphism, Genetic Peptidyl-Dipeptidase A Male Hungary Humans Genotype Female Diabetes Mellitus, Type 1 Child Blood Pressure Adolescent school child proteinuria polymerase chain reaction major clinical study insulin dependent diabetes mellitus human genetic polymorphism gene insertion Gene Deletion diastolic blood pressure controlled study circadian rhythm blood pressure monitoring ARTICLE Adult INSULIN dipeptidyl carboxypeptidase Children and adolescents Angiotensin-converting enzyme gene polymorphism Ambulatory blood pressure measurement
Megjelenés:	Diabetic Medicine. - 22 : 8 (2005), p. 1054-1059. -
További szerzők:	Soós Andrea Vámosi Ildikó
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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