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001-es BibID:	BIBFORM024865
Első szerző:	Seres Ildikó (biokémikus)
Cím:	Age-related alterations in PON1 / I. Seres, T. Fulop, G. Paragh, A. Khalil
Dátum:	2008
Megjegyzések:	Aging is associated with an increased incidence of atherosclerosis. Atherosclerosis is an inflammatory disease initiated by oxidized low density lipoprotein (oxLDL). High density lipoprotein (HDL) is a powerful antioxidant protecting LDL and itself from oxidation as well by detoxifying the hydroperoxides from oxLDL. The enzyme responsible, at least in part, for this antioxidant effect of HDL is its tightly associated paraoxonase (PON1). As PON1 is responsible for the antioxidant effect of HDL and the atherosclerosis related cardiovascular diseases are increasing with aging an alteration either in the PON1 expression and/or activity should occur with aging. Indeed, PON1 serum concentrations do not change with aging while its activity significantly decreases. This chapter will describe the putative causes of this altered PON1 activity at the environmental and genetic levels. The possibility of PON1 activity modulation will be also discussed
Tárgyszavak:	Orvostudományok Klinikai orvostudományok könyvfejezet
Megjelenés:	The Paraoxonases : their role in disease development and xenobiotic metabolism / ed. by Bharti Mackness, Mike Mackness, Michael Aviram, György Paragh. - p. 199-206. -
További szerzők:	Fülöp Tamás Jr Paragh György (1953-) (belgyógyász) Khalil, Abdelouahed
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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