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001-es BibID:BIBFORM028130
Első szerző:Ulloa, Luis
Cím:Dephosphorylation of distinct sites on microtubule-associated protein MAP1B by protein phosphatases 1, 2A and 2B / Luis Ulloa, Viktor Dombrádi, Javier Diaz-Nido, Kornélia Szűcs, Pál Gergely, Peter Friedrich, Jesús Avila
Dátum:1993
ISSN:0014-5793
Megjegyzések:Rat brain microtubule-associated protein MAP1B has been tested as a substrate for Ser/Thr protein phosphatases (PP). The dephosphorylation reactions were followed by specific antibodies recognizing phosphorylated and phosphorylatable epitopes. One set of phosphorylation sites on MAP1B are referred to as mode I sites, and their phosphorylation is presumably catalyzed by proline-directed protein kinases. These mode I sites are efficiently dephosphorylated by PP2B and 2A but not by PP1. Another set of phosphorylation sites on MAP1B are named mode II sites, and their phosphorylation is possibly due to casein kinase II. These mode II sites are dephosphorylated by PP2A and PP1, the PP2B being ineffective. The selectivity of phosphatases for different sites within the same protein indicates the complexity of the dephosphorylation reactions regulating the functionality of MAP1B in neurons.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
phosphorylation
dephosphorylation
microtubule-associated protein
protein phosphatase 1 and 2A
calcineurin
PDPK
casein kinase II
Megjelenés:Febs Letters. - 330 : 1 (1993), p. 85-89. -
További szerzők:Diaz-Nido, Javier Friedrich Péter Avilés, Jesús M. Dombrádi Viktor (1953-) (biokémikus) Szűcs Kornélia (1945-) (biokémikus) Gergely Pál (1947-) (biokémikus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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