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001-es BibID:	BIBFORM028141
Első szerző:	Dombrádi Viktor (biokémikus)
Cím:	Protein phosphorylation is involved in the regulation of chromatin condensation during interphase / Viktor Dombrádi, Patricia T. W. Cohen
Dátum:	1992
ISSN:	0014-5793
Megjegyzések:	Loci affecting the condensation state of interphase chromatin have been previously identified from analysis of suppression and enhancement of position effect variegation (PEV) in Drosophila. Here we show that Su-var(3)6 and an allelic mutant, e078, which both show suppression of PEV in the heterozygous state, have point mutations (Gly220-->Ser and Gly220-->Asp, respectively) in a protein phosphatase 1 catalytic subunit located at 87B (PP1 87B). The mutated glycine is conserved in all known protein serine/threonine phosphatases in the same gene family, and its substitution decreases PP1 activity. We conclude that protein dephosphorylation by PP1 87B regulates the condensation state of chromatin during interphase.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban protein phosphatase chromatin position effect variegation mitosis Drosophila
Megjelenés:	Febs Letters. - 312 : 1 (1992), p. 21-26. -
További szerzők:	Cohen, Patricia T. W.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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