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001-es BibID:	BIBFORM028157
Első szerző:	Dombrádi Viktor (biokémikus)
Cím:	Cloning and chromosomal localization of Drosophila cDNA encoding the catalytic subunit of protein phosphatase 1 alpha : high conservation between mammalian and insect sequences / Viktor Dombrádi, J. Myles Axton, David M. Glover, Patricia T. W. Cohen
Dátum:	1989
ISSN:	1432-1033
Megjegyzések:	A 1.2-kb clone containing the full coding sequence of a protein phosphatase 1 catalytic subunit has been isolated from a Drosophila head cDNA library. It encodes a polypeptide of 302 amino acids with a molecular mass of 34.5 kDa. The predicted protein sequence is 92% identical (94% similar) to rabbit protein phosphatase 1 alpha (PP-1 alpha) demonstrating strict conservation of the phosphatase catalytic subunit over a considerable evolutionary distance. Abundant 1.6-kb and 2.5-kb mRNA transcripts were detected throughout Drosophila development. The clone hybridised to four sites on Drosophila salivary gland polytene chromosomes. The major site is at 87B6-12 on the right arm of chromosome 3. In addition, there are three secondary sites, one on the same chromosome at 96A2-5 and two on the X chromosome at 9C1-2 and 13C1-2. Isolation of a further cDNA clone, hybridising to 9C1-2 and encoding part of the catalytic subunit 88% similar to Drosophila PP-1 alpha, proves the existence of at least two transcriptionally active genes for protein phosphatase 1.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Drosophila cloning phosphatase 1 külföldön készült közlemény
Megjelenés:	European Journal Of Biochemistry. - 183 : 3 (1989), p. 603-610. -
További szerzők:	Axton, Miles Glover, David Cohen, Patricia T. W.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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