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001-es BibID:	BIBFORM028423
Első szerző:	Ajuebor, Maureen N.
Cím:	Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation : evidence for an inhibitory loop involving endogenous IL-10 / Maureen N. Ajuebor, Anuk M. Das, László Virág, Roderick J. Flower, Csaba Szabó, Mauro Perretti
Dátum:	1999
ISSN:	1550-6606
Megjegyzések:	The roles played by resident macrophages (Mphi) and mast cells (MCs) in polymorphonuclear leukocyte (PMN) accumulation and chemokine production within the mouse peritoneal cavity in response to administration of zymosan (0.2 and 1 mg), LPS (1 mg/kg), and thioglycolate (0.5 ml of a 3% suspension) were investigated. A marked reduction (>95%) in intact MC numbers was obtained by pretreatment with the MC activator compound 48/80, whereas resident Mphi were greatly diminished (>85%) by a 3-day treatment with liposomes encapsulating the cytotoxic drug dichloromethylene-bisphosphonate. No modulation of thioglycolate-induced inflammation was seen with either pretreatment. Removal of either MCs or Mphi attenuated LPS-induced PMN extravasation without affecting the levels of the chemokines murine monocyte chemoattractant protein-1 and KC measured in the lavage fluids. In contrast, MC depletion inhibited PMN accumulation and murine monocyte chemoattractant protein-1 and KC production in the zymosan peritonitis model. Removal of Mphi augmented the accumulation of PMN elicited by the latter stimulus. This was due to an inhibitory action of Mphi-derived IL-10 because there was 1) a time-dependent release of IL-10 in the zymosan exudates; 2) a reduction in IL-10 levels following Mphi, but not MC, depletion; and 3) an increased PMN influx and chemokine production in IL-10 knockout mice. In conclusion, we propose a stimulus-dependent role of resident MCs in chemokine production and the existence of a regulatory loop between endogenous IL-10 and the chemokine-mediated cellular component of acute inflammation.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal Of Immunology 162 : 3 (1999), p. 1685-1691. -
További szerzők:	Das, Anuk M. Virág László (1965-) (biokémikus, sejtbiológus, farmakológus) Flower, Roderick J. Szabó Csaba (1967-) (orvos) Perretti, Mauro
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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