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001-es BibID:	BIBFORM028689
Első szerző:	Szondy Zsuzsanna (molekuláris sejtbiológus, biokémikus)
Cím:	The rate of the AMP/adenosine substrate cycle in concanavalin- A-stimulated rat lymphocytes / Zsuzsa Szondy, Eric A. Newsholme
Dátum:	1989
ISSN:	0264-6021
Megjegyzések:	The effect of adenosine on the metabolism of prelabelled adenine nucleotides was investigated in concanavalin-A-stimulated rat lymphocytes. Adenosine in the presence of the adenosine deaminase inhibitor, deoxycoformycin, caused a 2-fold increase in the ATP concentration. This effect was, in part, countereacted by an increased rate of adenine nucleotide catabolism, which could be explained by a stimulation of AMP deaminase (EC 3.5.4.6). At the same time a continuous rate of labelled adenosine production was found, which was not affected by the increased ATP concentration and which could only be detected by the trapping effect of a high concentration of added unlabelled adenosine. It is concluded that the rate of the substrate cycle between AMP and adenosine is low (1.9 +/- 0.2 nmol/h per 10(7) cells) in comparison to the rate of AMP deamination.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban külföldön készült közlemény
Megjelenés:	The Biochemical Journal. - 261 : 3 (1989), p. 739-742. -
További szerzők:	Newsholme, Eric A.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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