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001-es BibID:	BIBFORM030344
035-os BibID:	PMID:7721044 WOS:A1994QF05100019
Első szerző:	Nánási Péter Pál (élettanász)
Cím:	Effects of veratrine on ion currents in single rabbit cardiomyocytes / Péter P. Nanasi, András Varro, Shirley H. Bryant, David A. Lathrop
Dátum:	1994
ISSN:	0306-3623
Megjegyzések:	1. Voltage-clamp experiments were performed to determine the effects of veratrine (1 mu g/ml) on Na and K currents in isolated rabbit ventricular cardiomyocytes. 2. Veratrine did not affect the inward rectifier K current, increased the inactivation time constant of the transient outward current (I-to) and induced a slowly decaying inward current component (I-v), which was sensitive to tetrodotoxin. 3. Inactivation of fast Na channels by application of short depolarizing prepulses to potentials between -90 and -50 mV prevented the development of I-v. I-v decayed biexponentially with time constants equal to 139 +/- 9.0 ms and 776 +/- 47 ms. The net amplitude of I-v and the time constants for its rapidly and slowly inactivating components were little affected by trains of conditioning prepulses to 0 mV. The contributions, however, of the fast and slow components to the net current were significantly altered by repetitive depolarizations. 4. These components of I-v are likely due to modification of open cardiac Na channels by veratrum alkaloids.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	General Pharmacology. - 25 : 8 (1994), p. 1667-1672. -
További szerzők:	Varró András (1954-) (farmakológus, klinikai farmakológus) Bryant, Shirley H. Lathrop, David A.
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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