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001-es BibID:	BIBFORM030934
Első szerző:	Debbab, Abdessamad
Cím:	New Anthracene Derivatives - Structure Elucidation and Antimicrobial Activity / Abdessamad Debbab, Amal H. Aly, Ruangelie Edrada-Ebel, Victor Wray, Alexander Pretsch, Gennaro Pescitelli, Tibor Kurtan, Peter Proksch
Dátum:	2012
Megjegyzések:	Three new anthracene derivatives, which include tetrahydroanthraquinone 1 and two tetrahydroanthraquinone heterodimers 2 and 3, were isolated from Stemphylium globuliferum, together with four known metabolites 4-7. Detailed analysis of the spectroscopic data allowed the unambiguous determination of the structures of 1 and 2 and a revision of the structure of alterporriol C and its atropisomer. Furthermore, alterporriol G, previously obtained as part of a mixture, was isolated in its pure form for the first time and its structure was also revised. The absolute configurations of 1, 2 and 3 were assigned by calculation of their CD spectra, which also allowed the configurational assignment of altersolanol A and the determination of the axial chirality of alterporriols D and E. All isolated compounds were analysed for their antimicrobial and cytotoxic activities. Compound 5 inhibited the growth of most pathogenic microorganisms tested, whereas 2, 6 and 7 showed selective inhibition of bacteria but were inactive against fungi.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Molekulatudomány Natural products Medicinal chemistry Antibiotics Biological activity Quinones Structure elucidation Circular dichroism Density functional calculations
Megjelenés:	European Journal of Organic Chemistry. - 7 (2012), p. 1351-1359. -
További szerzők:	Aly, Amal H. Edrada-Ebel, Ruangelie Wray, Victor Pretsch, Alexander Pescitelli, Gennaro (1972-) (vegyész) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Proksch, Peter
Pályázati támogatás:	TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP O- és O,N heterociklusok szintézise és kiroptikai vizsgálata
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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