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001-es BibID:	BIBFORM031424
035-os BibID:	WOS:000264694500008 PMID:19260013
Első szerző:	Tompa Péter
Cím:	Close encounters of the third kind: disordered domains and the interactions of proteins / Peter Tompa, Monika Fuxreiter, Christopher J. Oldfield, Istvan Simon, A. Keith Dunker, Vladimir N. Uversky
Dátum:	2009
ISSN:	0265-9247
Megjegyzések:	Protein-protein interactions are thought to be mediated by domains, which areautonomous folding units of proteins. Recently, a second type of interaction hasbeen suggested, mediated by short segments termed linear motifs, which arerelated to recognition elements of intrinsically disordered regions. Here, wepropose a third kind of protein-protein recognition mechanism, mediated bydisordered regions longer than 20-30 residues. Bioinformatics predictions andwell-characterized examples, such as the kinase-inhibitory domain of Cdkinhibitors and the Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 ofactin-binding proteins, show that these disordered regions conform to thedefinition of domains rather than motifs, i.e., they represent functional,evolutionary, and structural units. Their functions are distinct from those ofshort motifs and ordered domains, and establish a third kind of interactionprinciple. With these points, we argue that these long disordered regions shouldbe recognized as a distinct class of biologically functional protein domains.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Bioessays. - 31 : 3 (2009), p. 328-335. -
További szerzők:	Fuxreiter Mónika (1969-) (kutató vegyész) Oldfield, Christopher J. Simon István Dunker, A. Keith Uversky, Vladimir N.
Pályázati támogatás:	K60694 OTKA NK71582 OTKA
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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