Összesen 1 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM033270
035-os BibID:WOS:000166627300004 PMID:11163624
Első szerző:Imre Sándor (pathofiziológus)
Cím:High sensitivity to autoxidation in neonatal calf erythrocytes : possible mechanism of accelerated cell aging / S. Imre, M. Csornai, M. Balazs
Dátum:2001
Megjegyzések:The suspension viscosity, formation of methaemoglobin and production of malondialdehyde (MDA) associated with the non-enzymatic oxidation of polyunsaturated fatty acids during auto-oxidation conditions in vitro have been compared in erythrocytes From young calves (2, 4 and 6 weeks of age) and mature cattle. The autoxidation conditions were designed to simulate the oxidative stress to which neonatal erythrocytes are exposed in vivo. Characterisation of lipid peroxidation was also undertaken by a combination of lipid fluorescent measurements and quantification of the superoxide: dismutase (SOD) activities of the erythrocytes, The results demonstrated that high SOD activities in the erythrocytes of the neonatal calf was insufficient to afford protection against the increased autoxidation of haemoglobin and subsequent accumulation of lipid peroxidation products, High levels of methaemoglobin formation and lipid peroxidation were able to provide an explanation for an observed reduction in rheological adaptability (increased suspension viscosity) and an accelerated aging of the neonatal cells under in vivo conditions.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Superoxide dismutase
Lipid peroxidation
Autoxidation
Rheology
Calf erythrocytes
egyetemen (Magyarországon) készült közlemény
Megjelenés:Mechanisms of ageing and development. - 122 : 1 (2001), p. 69-76. -
További szerzők:Csornai Márta Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus)
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1