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001-es BibID:	BIBFORM033685
035-os BibID:	WOS:A1997XB71100061
Első szerző:	Jungwirth, Andreas
Cím:	Growth hormone-releasing hormone antagonist MZ-4-71 inhibits in vivo proliferation of Caki-I renal adenocarcinoma / Andreas Jungwirth, Andrew V. Schally, Jacek Pinski, Kate Groot, Patricia Armatis, Gabor Halmos
Dátum:	1997
ISSN:	0027-8424
Megjegyzések:	In view of evidence that growth hormone (GH) and insulin-like growth factors (IGF) may play a role in the development of renal cell carcinoma (RCC), we investigated the effects of growth hormone-releasing hormone (GHRH) antagonist MZ-4-71 on the proliferation of the human renal adenocarcinoma cell line Caki-I in vitro and in vivo. Male nude mice bearing xenografts of human Caki-I RCC were treated for 4 weeks with MZ-4-71 injected s.c. twice daily at a dose of 20 mu g per animal, Tumor growth, serum, liver, and tumor IGF levels and IGF-I receptor concentrations in Caki-I cell membranes were measured. After 4 weeks of therapy, the final volume of Caki-I tumors in nude mice treated with MZ-4-71 was significantly (P < 0.01) decreased to 52.6 +/- 12.3 mm(3) as compared with controls that measured 504.2 +/- 104.1 mm(3), Treatment with GH-RH antagonist also significantly reduced tumor weight, serum levels of GH and IGF-I, liver concentrations of IGF-I, and tumor levels of IGF-I and IGF-II, High-affinity binding sites for IGF-I were detected in the cell membranes of Caki-I tumors, IGF-I and IGF-II stimulated the proliferation of Caki-I cells in tissue cultures, Antagonist MZ-4-71 could inhibit in vitro growth of Caki-I cells, but only at high concentrations, Our findings demonstrate that GH-RH antagonist MZ-4-71 can significantly inhibit the growth of Caki-I RCC, MZ-4-71 may exert its suppressive effect on tumor growth through a reduction in GH release from the pituitary and the subsequent decrease in the production of IGF-I in the liver and IGF-I and II by the tumors, The efficacy of MZ-4-71 suggests that this compound could be considered for the therapy of recurrent or metastatic RCC.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban külföldön készült közlemény
Megjelenés:	Proceedings of The National Academy of Sciences of The United States of America. - 94 : 11 (1997), p. 5810-5813. -
További szerzők:	Schally, Andrew Victor Pinski, Jacek Groot, Kate Armatis, Patricia Halmos Gábor (1962-) (gyógyszerész, receptorfarmakológus, experimentális onkológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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