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001-es BibID:BIBFORM034458
Első szerző:Davis, Kenneth L.
Cím:Ventricular enlargement in poor-outcome schizophrenia / Kenneth L. Davis, Monte S. Buchsbaum, Lina Shihabuddin, Jacqueline Spiegel-Cohen, Michael Metzger, Ede Frecska, Richard S. Keefe, Peter Powchik
Dátum:1998
ISSN:0006-3223
Megjegyzések:A subset of patients with schizophrenia, defined on the basis of longitudinal deficits in self-care, may show a classic ("Kraepelinian") degenerative course. An independent validator of the phenomenologically defined Kraepelinian subtype might be provided by a structural indicator of possible brain degeneration: ventricular size as measured by computed tomography (CT). To examine whether Kraepelinian patients would show a differential increase in ventricular size over time, two CT scans were conducted at intervals separated by > 4 years, an average of 5 years. Fifty-three male patients with DSM-III-R diagnoses of chronic schizophrenia were subdivided into Kraepelinian (n = 22; mean age = 42 +/- 6 years) and non-Kraepelinian (n = 31; mean age = 38 +/- 12.2 years) subgroups. Kraepelinian patients were defined on the basis of longitudinal criteria: > 5 years of complete dependence on others for life necessities and care, lack of employment, and sustained symptomatology. Thirteen normal elderly volunteers (mean age = 60 +/- 17.8) were also scanned at 4-year intervals. CT measurements were made by raters without knowledge of subgroup membership. A semiautomated computer program was used to trace the anterior horn, lateral ventricles, and temporal horns for each slice level on which they were clearly seen. The ventricles showed a bilateral increase in size over the 4-year interval in the Kraepelinian subgroup, more marked in the left hemisphere than the right. By contrast, neither the non-Kraepelinian subgroup nor the normal volunteers showed significant CT changes from scan 1 to scan 2. Thus, the longitudinal dysfunctions in self-care that characterize the Kraepelinian patients were associated with an independent indicator of brain abnormality.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
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külföldön készült közlemény
Megjelenés:Biological Psychiatry. - 43 : 11 (1998), p. 783-793. -
További szerzők:Buchsbaum, Monte S. Shihabuddin, Lina Spiegel-Cohen, Jacqueline Metzger, Michael Frecska Ede (1953-) (pszichiáter) Keefe, Richard S. Powchik, Peter
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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