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001-es BibID:	BIBFORM035327
Első szerző:	Bhattoa Harjit Pal (laboratóriumi szakorvos)
Cím:	Bone mineral density in women with systemic lupus erythematosus / H. P. Bhattoa, P. Bettembuk, A. Balogh, G. Szegedi, E. Kiss
Dátum:	2002
ISSN:	0770-3198
Megjegyzések:	The aim of this cross-sectional study was to determine the prevalence of reduced bone mineral density (BMD) in a group of female SLE patients and to identify factors predictive of reduced BMD. Femoral neck (FN) and lumbar spine (LS) dual-energy X-ray absorptiometry results wer evaluated in 79 pre- and postmenopausal women with SLE aged (mean, range) 49 (22-73) years). Variables evaluated were disease duration, SLEDAI, current and cumulative corticosteroid dose, Steinbrocker's functional classification, use of immunosuppressive agents, and history of fracture due to minor trauma. A T-score of ?ë♯n 1.0 was found in 61.9% at the LS and 48.3% at the FN, and 18 (23.7%) patients belonged to the category of osteoporosis at LS, compared to only three (5.4%) patients at FN. A statistical difference (P = 0.014) was found when comparing LS BMD in pre- and postmenopausal patients. LS BMD had a significant correlation with daily and cumulative steroid dose (P = 0.016 and 0.031, respectively). There was a significant difference in LS BMD between the daily steroid dose group receiving ?ë♯n 7.5 and those receiving > 7.5. mg/day (P = 0.008), and also in FN BMD comparing groups on 0 and > 7.5 mg/day (P = 0.022). There was significant difference in LS and FN BMD between patients in Steinbrocker classes I and III (P = 0.016 and 0.005, respectively). No significant correlation was found in either subgroup between BMD and other studied parameters. We concluded that the prevalence of reduced bone mass at LS is pronounced among postmenopausal women with SLE, in those with a high Steinbrocker functional classification and those on a high daily steroid dose. Therefore, these patients should be considered as a high-risk group deserving regular spinal BMD scans and therapy in time to prevent vertebral fractures.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény Bone mineral density Female Glucocorticoids Osteoporosis Systemic lupus erythematosus corticosteroid immunosuppressive agent adult aged article bone density bone mass bone mineral bone scintiscanning controlled study correlation analysis disease classification disease duration dose response dual energy X ray absorptiometry female femur neck high risk patient human lumbar spine osteoporosis postmenopause prediction premenopause prevalence priority journal scoring system systemic lupus erythematosus vertebra fracture age distribution cohort analysis comparative study cross-sectional study hospitalization Hungary middle aged physiology probability radiodensitometry risk assessment risk factor Adrenal Cortex Hormones Adult Age Distribution Aged Bone Density Cohort Studies Comparative Study Cross-Sectional Studies Densitometry, X-Ray Female Human Hungary Lupus Erythematosus, Systemic Middle Age Osteoporosis Prevalence Probability Risk Assessment Risk Factors Severity of Illness Index Support, Non-U.S. Gov't Humans Middle Aged
Megjelenés:	Clinical Rheumatology. - 21 : 2 (2002), p. 135-141. -
További szerzők:	Bettembuk Péter Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos) Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Kiss Emese (1960-) (belgyógyász, immunológus)
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