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001-es BibID:	BIBFORM035328
Első szerző:	Kiss Emese (belgyógyász, immunológus)
Cím:	Pregnancy in women with systemic lupus erythematosus / Emese Kiss, Harjit P. Bhattoa, Peter Bettembuk, Adam Balogh, Gyula Szegedi
Dátum:	2002
ISSN:	0301-2115
Megjegyzések:	Background: Systemic lupus erythematosus (SLE) is an autoimmune disorder which may be affected by hormonal changes, such as those of pregnancy. Women with SLE have increased adverse pregnancy outcomes. Study design: A retrospective analysis of the gynecologic and immunologic case history of 140 women with SLE and the outcome of 263 pregnancies in 99 women with SLE. Results: In patients diagnosed with SLE, the proportion of pregnancies ending with live birth at term decreased to one-third compared with three quarters in those without a diagnosis of SLE and the incidence of pre-term deliveries and spontaneous abortions increased by 6.8 and 4.7 times, respectively. When SLE was associated with secondary antiphospholipid (APL) syndrome, and lupus anticoagulant (LA) or ??2-glycoprotein antibodies were present, a further increase in the incidence of pregnancy loss was observed. Pregnancy did not cause a flare-up of SLE in all cases, the disease remained stable in about 30% of the patients. Lupus was mild in the majority of the women who carried out their pregnancy to term. We also observed mothers with active SLE who successfully carried out pregnancies to term. Conclusion: These findings accord with previous literature and should inform rheumatologists, obstetricians and neonatologists who guide patients in their reproductive decisions.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény Lupus anticoagulant Pregnancy Spontaneous abortion Systemic lupus erythematosus lupus anticoagulant adult antiphospholipid syndrome article female human incidence induced abortion major clinical study pregnancy priority journal risk spontaneous abortion systemic lupus erythematosus thrombosis Adolescent Adult Aged Female Humans Lupus Erythematosus, Systemic Middle Aged Pregnancy Pregnancy Complications Pregnancy Outcome Retrospective Studies
Megjelenés:	European Journal of Obstetrics Gynecology and Reproductive Biology. - 101 : 2 (2002), p. 129-134. -
További szerzők:	Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Bettembuk Péter Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos) Szegedi Gyula (1936-2013) (belgyógyász, immunológus)
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat DOI
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