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001-es BibID:	BIBFORM036716
035-os BibID:	PMID:22843098
Első szerző:	Dull Katalin (molekuláris biológus, genetikus)
Cím:	Mitotic failures in cancer : aurora B kinase and its potential role in the development of aneuploidy / Katalin Hegyi, Gábor Méhes
Dátum:	2012
ISSN:	1219-4956
Megjegyzések:	One of the basic requirements during the process of cell division is to maintain genetic integrity and ensure normal ploidy. The family of Aurora kinases, composed of Aurora A, B and C, takes a major role in the control of centrosome cycle, mitotic entry, chromosome condensation and coordination of chromosomal movements. Deregulation of kinase expression was described in a series of different malignancies which was also associated with aneuploidy. Recently, Aurora kinases gained significant interest as potential therapeutic targets in oncology. While there is increasing evidence about the activities of Aurora A kinase during cancer progression, data are controversial regarding the role of Aurora B. In this review the biology of Aurora kinases and its potential relation to cancer progression is discussed with special focus on functional changes and determination of Aurora B kinase.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Pathology and Oncology Research. - 18 : 4 (2012), p. 761-769. -
További szerzők:	Méhes Gábor (1966-) (patológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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