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001-es BibID:BIBFORM037167
Első szerző:Pallai Anna (biokémikus, molekuláris biológus)
Cím:Glutamyl-Lysine Isodipeptide Produced By Transglutaminase Inhibits The Proinflammatory Cytokine Production Of Lps Stimulated Macrophages / Anna Pallai, Zsolt Sarang, Zsuzsa Szondy
Dátum:2012
Megjegyzések:Transglutaminase is a multi-functional enzyme that post-translationally modifies proteins by catalyzing the formation of intermolecular epsilon-(gamma-glutamyl)-lysyl bonds between glutamine and lysine side chains.In apoptotic cells tissue transglutaminase (TG2) is upregulated and activated. The enzyme can stabilize the apoptotic bodies by forming glutamyl-lysyl isopeptide bonds between its target proteins. When apoptotic cells are phagocytosed, their content is degraded in phagolysosomes. The gamma-glutamyl-lysyl bonds are resistant to lysosomal proteases and the phagocytes secrete epsilon-(gamma-glutamyl)-lysine isodipeptides to their environment. Increased plasma level of isodipeptide molecule indicates the rate of apoptosis though the possible physiological effects of the isodipeptide haven't been investigated yet.In our experiments we found, that this isodipeptide has potential anti-inflammatory effect. It can decrease the expression of LPS-induced TNF-alpha, IL-6, MIP-2 and iNOS in primer mouse macrophages and RAW264 mouse macrophage cell line. In the future we would like to characterize the effect of the molecule on inflammation, migration and phagocytotic capacity.
ISBN:978-953-95551-4-4
Tárgyszavak:Természettudományok Biológiai tudományok előadáskivonat
Isodipetide
Megjelenés:FEBS3 + Meeting From molecules to life and back, Book of abstracts / eds. Jerka Dumic, Zrinka Kovarik, Jadranka Varljen. - p. 105. -
További szerzők:Sarang Zsolt (1976-) (mikrobiológus) Szondy Zsuzsanna (1959-) (molekuláris sejtbiológus, biokémikus)
Pályázati támogatás:TÁMOP-4.2.2/B-10/1-2010-0024
TÁMOP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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