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001-es BibID:	BIBFORM037301
Első szerző:	Vasanthi, Hannah Rachel
Cím:	Protective role of air potato (Dioscorea bulbifera) of yam family in myocardial ischemic reperfusion injury / Vasanthi Hannah Rachel, Mukherjee Subhendu, Ray Diptarka, Pandian Jayachandran Karuppiah Shanmugasundara, Lekli Istvan, Das Dipak Kumar
Dátum:	2010
ISSN:	2042-6496
Megjegyzések:	Hydroalcoholic extract of Dioscorea bulbifera (DB), a yam variety called air potato, was tested for its protective effect on myocardial ischemic/reperfusion (I/R) injury in rats due to apoptosis and necrosis. Myocardial I/R injury was induced by 30 min ischemia followed by 2 h reperfusion by perfusing isolated rat hearts with Krebs Henseilet bicarbonate (KHB) buffer in a Langendorff set up. Pretreatment of DB (150 mg kg(-1) body weight) for 30 days significantly reduced myocardial infarct size and improved the ventricular function (aortic flow and coronary flow, LVDP, LVmax dp/dt). Role of DB on apoptosis was also evaluated by determining caspase 3 as well as by examining pro-apoptotic and anti-apoptotic proteins Bax and Bcl2 by Western blot analysis followed by TUNEL assay. DB also prevented I/R-mediated down regulation of survival protein Akt and HO-1. Our results indicated that Dioscorea bulbifera could ameliorate myocardial ischemia and reperfusion injury by improving ventricular function and inhibition of cardiomyocyte necrosis and apoptosis
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Food & Function. - 1 : 3 (2010), p. 278-283. -
További szerzők:	Mukherjee, Subhendu Ray, Diptarka Pandian Jayachandran, Karuppiah Shanmugasundara Lekli István (1981-) (gyógyszerész) Das, Dipak Kumar
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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