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001-es BibID:BIBFORM039005
035-os BibID:PMID:15572026
Első szerző:Kashuba, Elena
Cím:Epstein-Barr virus-encoded EBNA-5 binds to Epstein-Barr virus-induced Fte1/S3a protein / Elena Kashuba, Mariya Yurchenko, Krisztina Szirák, Joachim Stahl, George Klein, László Székely
Dátum:2005
ISSN:0014-4827
Megjegyzések:Epstein-Barr virus (EBV) transforms resting human B cells into immortalized immunoblasts. EBV-encoded nuclear antigens EBNA-5 (also called EBNA-LP) is one of the earliest viral proteins expressed in freshly infected B cells. We have recently shown that EBNA-5 binds p14ARF, a nucleolar protein that regulates the p53 pathway. Here, we report the identification of another protein with partially nucleolar localization, the v-fos transformation effector Fte-1 (Fte-1/S3a), as an EBNA-5 binding partner. In transfected cells, Fte-1/S3a and EBNA-5 proteins showed high levels of colocalization in extranucleolar inclusions. Fte-1/S3a has multiple biological functions. It enhances v-fos-mediated cellular transformation and is part of the small ribosomal subunit. It also interacts with the transcriptional factor CHOP and apoptosis regulator poly(ADP-ribose) polymerase (PARP). Fte-1/S3a is regularly expressed at high levels in both tumors and cancer cell lines. Its high expression favors the maintenance of malignant phenotype and undifferentiated state, whereas its down-regulation is associated with cellular differentiation and growth arrest. Here, we show that EBV-induced B cell transformation leads to the up-regulation of Fte-1/S3a. We suggest that EBNA-5 through binding may influence the growth promoting, differentiation inhibiting, or apoptosis regulating functions of Fte-1/S3a.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Epstein-Barr virus
EBNA-5
Fte-1/S3a ribosomal protein
Cell transformation
Yeast two-hybrid system
külföldön készült közlemény
Megjelenés:Experimental Cell Research. - 303 : 1 (2005), p. 47-55. -
További szerzők:Yurchenko, Mariya Stahl, Joachim Klein, George Székely László Szirák Krisztina (1973-) (molekuláris genetikus)
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