Találati lista | Tudóstér

001-es BibID:	BIBFORM039180
Első szerző:	Póka Róbert (szülész-nőgyógyász, klinikai onkológus)
Cím:	Stage-related superoxide anion production of granulocytes of gynecologic cancer patients / R. Póka, S. Szűcs, R. Ádány, E. Szikszay
Dátum:	2000
Megjegyzések:	OBJECTIVE: To measure superoxide anion production of polymorphonuclear leukocytes(PMNLs) in 58 gynecologic cancer patients and compare to that of healthycontrols. METHODS: PMNLs were separated from peripheral blood samples by Ficolland subsequent Percoll gradient sedimentation. Baseline and phorbol-dibutyrate(100 nmol/l) stimulated superoxide anion production was measuredspectrophotometrically as superoxide dismutase inhibitable reduction offerricytochrome c (50 micromol/l) absorbance. Differences between the meansuperoxide anion production of different patient groups and the control groupwere assessed by Student's t-test. RESULTS: The mean superoxide anion productionof PMNLs of healthy controls was 1.855 nM/min/3 x 10(5) cells (SD=0.211 nM/min/3x 10(5) cells). Superoxide anion production of gynecologic cancer patients andhealthy controls varied in a wide range. PMNLs of patients had lower baseline andstimulated activity than those of healthy volunteers. The frequency of a meansuperoxide production at least 2 x SD below the control showed a parallelincrease with advancing stage. CONCLUSION: Granulocytes of gynecologic cancerpatients have reduced capacity and inducibility of superoxide anion productionalready at an early stage of disease.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban 0 (Anions) 0 (Cytochrome c Group) 11062-77-4 (Superoxides) 37558-16-0 (Phorbol 12,13-Dibutyrate) EC 1.15.1.1 (Superoxide Dismutase) Anions Cytochrome c Group/metabolism Endometrial Neoplasms/blood/pathology Female Genital Neoplasms, Female/blood/pathology Humans Neoplasm Staging Neutrophils/metabolism Ovarian Neoplasms/blood/pathology Phorbol 12,13-Dibutyrate/pharmacology Spectrophotometry Superoxide Dismutase/pharmacology Superoxides/blood Uterine Cervical Neoplasms/metabolism/pathology Vulvar Neoplasms/blood/pathology
Megjelenés:	European Journal of Obstetrics, Gynecology, and Reproductive Biology. - 89 : 1 (2000), p. 55-57. -
További szerzők:	Szűcs Sándor (1958-) (biokémikus, vegyész) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Szikszay Edit
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
Borító:
Saját polcon: