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001-es BibID:	BIBFORM040097
Első szerző:	Kovács László (élettanász)
Cím:	Calcium transients and calcium binding to troponin at the contraction threshold in skeletal muscle / Kovacs, L., Szucs, G., Csernoch, L.
Dátum:	1987
ISSN:	0006-3495
Megjegyzések:	Antipyrylazo III calcium transients from voltage-clamped, cut skeletal muscle fibers of the frog were recorded, and the calcium binding to the regulatory sites of troponin C was calculated. The strength-duration curve for the contraction threshold was determined. It was found that the increase in myoplasmic calcium concentration necessary to produce the same level of contractile activation, i.e., the just visible movement, was approximately 60% higher at more positive membrane potentials resulting from short depolarizing pulses than at rheobase. However, using biochemical data for the kON and kOFF rate coefficients of the binding sites, the calculated maximums of the calcium binding curves were about the same at different voltages, and the time to maximum saturation was roughly equal to the latency of the contractions. To characterize the calcium binding in intact fibers more accurately, those values of the kON and kOFF rate coefficients that gave equal peak saturations during threshold movement at different membrane potentials were determined.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Biophysical Journal. - 51 : 4 (1987), p. 521-526. -
További szerzők:	Szűcs Géza (1948-) (élettanász) Csernoch László (1961-) (élettanász)
Internet cím:	elektronikus változat Intézményi repozitóriumban (DEA) tárolt változat
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