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001-es BibID:	BIBFORM040313
035-os BibID:	PMID:20876196
Első szerző:	Luz, Liliana L.
Cím:	Monosynaptic excitatory inputs to spinal lamina I anterolateral-tract-projecting neurons from neighbouring lamina I neurons / Liliana L. Luz, Peter Szucs, Raquel Pinho, Boris V. Safronov
Dátum:	2010
ISSN:	0022-3751
Megjegyzések:	Spinal lamina I receives nociceptive primary afferent input to project through diverse ascending pathways, including the anterolateral tract (ALT). Large projection neurons (PNs) form only a few per cent of the cell population in this layer, and little is known about their local input from other lamina I neurons. We combined single-cell imaging in the isolated spinal cord, paired recordings, 3-D reconstructions of biocytin-labelled neurons and computer simulations to study the monosynaptic input to large ALT-PNs from neighbouring (somata separated by less than 80 m) large lamina I neurons. All 11 connections identified were excitatory. We have found that an axon of a presynaptic neuron forms multiple synapses on an ALT-PN, and both Ca(2+)-permeable and Ca(2+)-impermeable AMPA receptors are involved in transmission. The monosynaptic EPSC latencies (1-12 ms) are determined by both post- and presynaptic factors. The postsynaptic delay, resulting from the electrotonic EPSC propagation in the dendrites of an ALT-PN, could be 4 ms at most. The presynaptic delay, caused by the spike propagation in a narrow highly branched axon of a local-circuit neuron, can be about 10 ms for neighbouring ALT-PNs and longer for more distant neurons. In many cases, the EPSPs evoked by release from a lamina I neuron were sufficient to elicit a spike in an ALT-PN. Our data show that ALT-PNs can receive input from both lamina I local-circuit neurons and other ALT-PNs. We suggest that lamina I is a functionally interconnected layer. The intralaminar network described here can amplify the overall output from the principal spinal nociceptive projection area.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban külföldön készült közlemény
Megjelenés:	Journal of Physiology. - 588 : 22 (2010), p. 4489-4505. -
További szerzők:	Szűcs Péter (1974-) (kutatóorvos) Pinho, Raquel Safronov, Boris V.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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