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001-es BibID:	BIBFORM040516
035-os BibID:	PMID:2432773
Első szerző:	Polgár Katalin
Cím:	Immunocytochemical characterization of amniotic fluid macrophages in cases of fetal neural tube defects / Katalin Polgar, György Abel, Jeno Laczko, Sandor Sipka, Zoltan Papp
Dátum:	1987
Megjegyzések:	Amniotic fluid cells from 31 pregnancies with fetuses having open neural tube defects (NTDs) and from 43 pregnancies with fetuses free of NTDs were studied with the use of the immunoperoxidase method for alpha-fetoprotein (AFP) and glial fibrillary acidic protein (GFAP). The authors also used cytochemical stains for endogenous peroxidase and nonspecific esterase activity. In cases of NTDs, macrophages were present in the amniotic fluid, and in the authors' system they showed intense immunoreactivity for both AFP and GFAP and showed very strong activity for peroxidase and nonspecific esterase, whereas the epithelial cells and red blood cells showed no activity. In six cases of anencephaly, sections from the margin of the cranial end of defective spinal cords at the aperture of the open lesion were also studied for AFP and GFAP. In these cases, AFP- and GFAP-positive cells were found, indicating the possible neural (glial) origin of a part of amniotic fluid macrophages. Although the determination of AFP levels in maternal blood and amniotic fluid is widely used in the prenatal diagnosis of NTDs, demonstration of AFP in amniotic fluid cells by means of immunocytochemistry has not been described.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	American Journal of Clinical Pathology. - 87 : 1 (1987), p. 37-42. -
További szerzők:	Ábel György Laczkó Jenő Papp Zoltán (1942-) (szülész-nőgyógyász, genetikus) Sipka Sándor (1945-) (laboratóriumi szakorvos)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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