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001-es BibID:	BIBFORM041173
Első szerző:	Burch, Henry B.
Cím:	Nucleotide and amino acid homology between the human thyrotropin receptor and the HIV-1 nef protein: Identification and functional analysis / Burch Henry B., Nagy Endre V., Lukes Yvonne G., Wartofsky Leonard, Burman Kenneth D.
Dátum:	1991
ISSN:	0006-291X
Megjegyzések:	A comparison of the nucleotide sequence of the human thyrotropin receptor (hTSH-R) with that of HIV-1 revealed 61% homology between a 161 base pair region encoding a unique portion of the hTSH-R and an immunogenic HIV-1 regulatory protein, nef. Amino acid analysis of this region shows 27% homology, including a segment in which 7/10 consecutive amino acids are identical. Sera from rabbits successfully immunized with a 16 amino acid portion of the hTSH-R (352-367, p1) was assessed for reactivity against a partially homologous nef peptide (nef-1) by ELISA, with a finding five-fold higher post-immunization values compared to pre-immune sera. The specificity of this response was verified with Western blot, using recombinant nef protein. An ELISA using nef-1 gave 64% higher values with sera from Graves' disease patients than with normal controls. This homology and immunologic cross-reactivity suggests an avenue through which a shared immune response against an HIV-1 related retrovirus could play a role in the pathogenesis of Graves' disease.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Biochemical And Biophysical Research Communications. - 181 : 1 (1991), p. 498-505. -
További szerzők:	Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Lukes, Yvonne G. Wartofsky, Leonard Burman, Kenneth D.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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