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001-es BibID:	BIBFORM041207
035-os BibID:	PMID:9362254
Első szerző:	Tósaki Árpád (kísérletes farmakológus, gyógyszerész)
Cím:	Ischemic preconditioning triggers phospholipase D signaling in rat heart / Arpad Tosaki, Nilanjana Maulik, Gerald Cordis, Ovidiu C. Trifan, Laurentiu M. Popescu, Dipak K. Das
Dátum:	1997
ISSN:	0002-9513
Megjegyzések:	Recent studies have indicated that repeated brief episodes of ischemia and reperfusion render the myocardium more tolerant to subsequent lethal ischemic injury. In view of the previous observations that ischemia-reperfusion potentiates phospholipase D signaling and that such signaling is beneficial for the heart, we investigated whether a similar phospholipase D signaling is responsible for the beneficial effects associated with repeated ischemia and reperfusion. Using an isolated perfused working rat heart model, we demonstrated that four brief episodes of 5 min of ischemia and 10 min of reperfusion reduced the incidence of ventricular arrhythmias, enhanced the postischemic ventricular performance, and decreased the release of creatine kinase from the reperfused heart, with simultaneous activation of phospholipase D generating the second messengers diacylglycerol and phosphatidic acid and leading to the translocation and activation of protein kinase C. The specific antiphospholipase D antibody blocked the activation of phospholipase D and attenuated the generation of diacylglycerol and phosphatidic acid and activation of protein kinase C. In concert, phospholipase D inhibition increased the incidence of ventricular arrhythmias, blocked the beneficial effects of preconditioning on the ventricular performance, and increased the amount of creatine kinase release from the coronary effluent. The results of this study indicate that repeated brief episodes of ischemia and reperfusion exert beneficial effects on the intact rat heart by triggering the activation of a phospholipase D signaling mechanism.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban külföldön készült közlemény
Megjelenés:	American Journal of Physiology. - 273 : 4 Pt. 2 (1997), p. H1860-H1866. -
További szerzők:	Maulik, Nilanjana Cordis, Gerald A. Trifan, Ovidiu C. Popescu, Laurenciu M. Das, Dipak Kumar
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat Szerző által megadott URL
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