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001-es BibID:	BIBFORM041435
Első szerző:	Zhou, Yaming
Cím:	Alkaloids from the Sponge-Associated Fungus Aspergillus sp. / Yaming Zhou, Abdessamad Debbab, Attila Mándi, Victor Wray, Barbara Schulz, Werner E. G. Müller, Matthias Kassack, WenHan Lin, Tibor Kurtán, Peter Proksch, Amal H. Aly
Dátum:	2013
Megjegyzések:	Seven new alkaloids including tryptoquivaline K (1) and fumiquinazolines K-P (2-7), bearing a rare 1-aminocyclopropane-1-carboxylic acid residue, together with six known compounds (8-13), were isolated from the fungus Aspergillus sp. obtained from the Mediterranean sponge Tethya aurantium. The structures of the new compounds were determined by extensive analysis by 1D and 2D NMR spectroscopy and mass spectrometry. The absolute configurations of tryptoquivaline K (1) and fumiquinazolines K and L (2, 3) were determined by TDDFT ECD calculations of their solution conformers, and the configurational assignment of the related fumiquinazolines M-P (4-7) was achieved by comparison of their ECD spectra with those of compounds 2 and 3. All compounds were evaluated for their cytotoxic activity by the MTT method. Compound 8 exhibited pronounced cytotoxicity against the mouse lymphoma cell line (L5178Y) with an IC50 value of 3.6 ?M, but only moderate activity was observed against human ovarian cancer (A2780) and human Philadelphia chromosome-positive chronic myelogenous leukemia (K562) cell lines with IC50 values of 18.5 and 15.0 ?M, respectively.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Natural products Alkaloids Circular dichroism Configuration determination Structure elucidation Density functional calculations
Megjelenés:	European Journal of Organic Chemistry. - 2013 : 5 (2013), p. 894-906. -
További szerzők:	Debbab, Abdessamad Mándi Attila (1981-) (vegyész, német szakfordító) Wray, Victor Schulz, Barbara Müller, Werner E. G. Kassack, Matthias Lin, Wen Han Kurtán Tibor (1973-) (vegyész, angol szakfordító) Proksch, Peter Aly, Amal H.
Pályázati támogatás:	HURO/0901/274/2.2.2 Egyéb NIIFI 10038 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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