Összesen 1 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM042248
Első szerző:Nagy László (molekuláris sejtbiológus, biokémikus)
Cím:Would eating carrots protect your liver? A new role involving NKT cells for retinoic acid in hepatitis / Laszlo Nagy
Dátum:2012
ISSN:0014-2980
Megjegyzések:Retinoic acid (RA), which is the biologically active form of vitamin A, acts through the nuclear hormone receptor RAR (RA receptor) to induce either gene activation or repression. RA production and its effects have been linked to macrophages, dendritic cells, T and B cells, and iNKT cells in the immune system and play pro- as well as anti-inflammatory roles depending on the cell type and the immune context. In this issue of the European Journal of Immunology, Lee et al. [Eur. J. Immunol. 2012. 42: 1685-1694] show that RA ameliorates Con A-induced murine hepatitis by selectively downmodulating IFN-γ and IL-4 production in disease-causing NKT cells in the liver. Remarkably, this effect is restricted to this liver disease model and does not apply to αGalCer-induced murine liver injury, which is driven by other cytokines. The study identifies retinoid signaling as an important endogenous mechanism controlling immune reactions and also as a potential pharmacological target for treatment of hepatic liver injury. Furthermore, the study by Lee et al. provides additional support for the concept of metabolic regulation of immune function.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Molekuláris Medicina
Megjelenés:European Journal Of Immunology. - 42 : 7 (2012), p. 1677-1680. -
Pályázati támogatás:NK72730
OTKA
K100196
OTKA
REGPOT-2008-1-01/MOLMEDREX/229920
FP7
TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
Magreceptor természetes ligandok azonosítása
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1