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001-es BibID:	BIBFORM042744
Első szerző:	Góth László (analitikus)
Cím:	Acatalasemia and diabetes mellitus / László Góth, Teréz Nagy
Dátum:	2012
Megjegyzések:	The enzyme catalase catalyzes the breakdown of hydrogen peroxide into oxygen and water. It is the mainregulator of hydrogen peroxide metabolism. Hydrogen peroxide is a highly reactive small moleculeformed as a natural byproducts of energy metabolism. Excessive concentrations may cause significantdamages to protein, DNA, RNA and lipids. Low levels in muscle cells, facilitate insulin signaling. Acatalasemiais a result of the homozygous mutations in the catalase gene, has a worldwide distribution with 12known mutations. Increased hydrogen peroxide, due to catalase deficiency, plays a role in the pathogenesisof several diseases such as diabetes mellitus. Diabetes mellitus is a disorder caused by multiplegenetic and environmental factors. Examination of Hungarian diabetic and acatalasemic patients showedthat an increased frequency of catalase gene mutations exists among diabetes patients. Inherited catalasedeficiency may increase the risk of type 2 diabetes mellitus, especially for females. Early onset of type 2diabetes occurs with inherited catalase deficiency. Low levels of SOD and glutathione peroxidase couldcontribute to complications caused by increased oxidative stress.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban acatalasemia diabetes reactive oxygen species catalse hydrogen peroxide
Megjelenés:	Arcives of Biochemistry and Biophysics. - 525 : 2 (2012), p. 195-200. -
További szerzők:	Nagy Teréz (1971-) (molekuláris biológus)
Pályázati támogatás:	T 71902 OTKA
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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