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001-es BibID:	BIBFORM043019
035-os BibID:	PMID:22997049
Első szerző:	Fábián Ákos István (aneszteziológus)
Cím:	The hitchhikers guide to cancer stem cell theory : markers, pathways and therapy / Ákos Fábián, György Vereb, János Szöllősi
Dátum:	2013
Megjegyzések:	Cancer stem cell (CSC) biology is a rapidly developing field within cancer research. CSCs are postulated to be a unique cell population exclusively capable of infinite self renewal, multilineage differentiation and with ability to evade conventional cytotoxic cancer therapy. These traits distinguish CSCs from their more differentiated counterparts, which possess only limited or no potential for self renewal and tumor initiation. Therefore, CSCs would be the driving motor of malignant growth and therapy resistance. Accordingly, successful cancer treatment would need to eliminate this highly potent group of cells, since even small residual numbers would suffice to recapitulate the disease after therapy. Putative CSCs has been identified in a broad range of human malignancies and several cell surface markers have been associated with their stem cell phenotype. Despite all efforts, a pure CSC population has not been isolated and often in vitro clonogenic and in vivo tumorigenic potential is found in several cell populations with occasionally contradictory surface marker signatures. Here, we give a brief overview of recent advances in CSC theory, including the signaling pathways in CSCs that also appear crucial for stem cells homeostasis in normal tissues. We discuss evidence for the interaction of CSCs with the stromal tumor environment. Finally, we review the emerging potentially effective CSC-targeted treatment strategies and their future role in therapy. (c) 2012 International Society for Advancement of Cytometry
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban article Biophysics cell biology cell surface Cells cytometry differentiation GROWTH Homeostasis Human Hungary In Vitro Phenotype Research review stem cell therapy
Megjelenés:	Cytometry. Part A. - 83 : 1 (2013), p. 62-71. -
További szerzők:	Vereb György (1965-) (biofizikus, orvos) Szöllősi János (1953-) (biofizikus)
Pályázati támogatás:	NK 101337 OTKA K 75752 OTKA TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP Receptor tirozin kinázok mint terápiás célpontok: működésük szabályozásának, és a közöttük fellépő molekuláris kölcsönhatások vizsgálata Baross Gábor Program REG_EA_09-1-2009-0010 Egyéb
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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