Találati lista | Tudóstér

001-es BibID:	BIBFORM044277
Első szerző:	Vannay Ádám
Cím:	Increased expression of hypoxia-inducible factor 1alpha in coeliac disease / Vannay Ádám, Sziksz Erna, Prókai Ágnes, Veres Gábor, Molnár Kriszta, Nagy Szakál Dorottya, Ónódy Anna, Korponay-Szabó Ilma R., Szabó András, Tulassay Tivadar, Arató András, Szebeni Beáta
Dátum:	2010
ISSN:	0031-3998
Megjegyzések:	Previously, it has been suggested that hypoxia-inducible factor (HIF) 1 signaling may play determinative role in the maintenance of the barrier function of the intestinal epithelium in inflammatory bowel disease. Our aim was to depict the alteration of HIF-1alpha and related genes in celiac disease (CD) where the importance of the barrier function is well known. Duodenal biopsy specimens were collected from 16 children with untreated CD, 9 children with treated CD and 10 controls. HIF-1alpha, trefoil factor 1 (TFF1), ecto-5-prime nucleotidase (CD73), and multi drug resistance gene 1 (MDR1) mRNA and HIF-1alpha protein expression were determined by real-time PCR and Western blot, respectively. Localization of HIF-1alpha was determined by immunofluorescent staining. We found increased HIF-1alpha and TFF1 mRNA and HIF-1alpha protein expression in the duodenal mucosa of children with untreated CD compared with controls or children with treated CD (p < 0.05). In untreated CD children, HIF-1alpha staining was present in cytoplasmic and nuclear region of the villous enterocytes. In treated CD mRNA expression of CD73 and MDR1 were increased compared with controls (p < 0.01 and 0.05, respectively). Our results of increased mucosal HIF-1alpha expression in CD children suggest the contribution of this signaling pathway in the pathomechanism of CD.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Pediatric Research. - 68 : 2 (2010), p. 118-122. -
További szerzők:	Sziksz Erna Prokai Ágnes Veres Gábor (1969-2020) (csecsemő- és gyermekgyógyász, gasztroenterológus) Molnár Kriszta Nagy Szakál Dorottya Ónody Anna Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Szabó András (gyermekgyógyász) Tulassay Tivadar Arató András Szebeni Beáta
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: