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001-es BibID:	BIBFORM046410
Első szerző:	Literáti-Nagy Zsuzsanna
Cím:	Synergetic Insulin Sensitizing Effect of Rimonabant and BGP-15 in Zucker-Obes Rats / Zsuzsanna Literati-Nagy, Kálmán Tory, Botond Literáti-Nagy, Ágnes Bajza, László Vígh Jr., László Vígh, József Mandl, Zoltán Szilvássy
Dátum:	2013
ISSN:	1219-4956 1532-2807
Megjegyzések:	Abdominal obesity is referred for as a commonpathogenic root of multiple risk factors, which include insulinresistance, dyslipidemia, hypertension, and a pro-atherogenicand pro-inflammatory state. Irrespective of its psychiatric sideeffects, rimonabant through blocking cannabinoid-1 receptor(CB1R) induces an increase in whole body insulin sensitivity.The aim of this work was to study the effect of selected dosesof another insulin sensitizer compound BGP-15, andrimonabant on insulin resistance in Zucker obese rats with apromise of inducing insulin sensitization together at lowerdoses than would have been expected by rimonabant alone.We found that BGP-15 potentiates the insulin sensitizing effectof rimonabant. The combination at doses, which do not induceinsulin sensitization by themselves, improved insulin signaling.Furthermore our results suggest that capsaicin-inducedsignal may play a role in insulin sensitizing effect of bothmolecules. Our data might indicate that a lower dose ofrimonabant in the treatment of insulin resistance and type 2diabetes is sufficient to administer, thus a lower incidence ofthe unfavorable psychiatric side effects of rimonabant are to beexpected.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Rimonabant BGP-15 Insulin resistance Obesity Capsaicin Glucose clamp
Megjelenés:	Pathology & Oncology Research. - 12253 (2013), p. 1-5. -
További szerzők:	Tory Kálmán Literáti-Nagy Botond Bajza Ágnes (1970-) (biológus) Vígh László Jr. Vígh László (orvos Szeged) Mandl József Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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