Találati lista | Tudóstér

001-es BibID:	BIBFORM046502
Első szerző:	Pálvölgyi Attila
Cím:	Interplay between nitric oxide and VIP in CCK-8-induced phasic contractile activity in the rabbit sphincter of Oddi / Attila Pálvölgyi, Réka Sári, József Németh, Annamária Szabolcs, István Nagy, Péter Hegyi, János Lonovics, Zoltán Szilvássy
Dátum:	2005
ISSN:	1007-9327
Megjegyzések:	AIM: The sphincter of Oddi (SO) plays an important role indelivery of bile into the duodenum. To establish whethervasoactive intestinal polypeptide (VIP) and nitric oxide (NO)were involved in phasic contractile activity of the rabbitSO stimulated by cholecystokinin-octapeptide (CCK-8).METHODS: Isolated SO muscle rings were cleaned of fatand mounted horizontally on two small L-shaped hooksone of which was connected to a force transducer for themeasurement of isometric tension. The experiments werecarried out in a thermostatically controlled (37?0.2 )organ bath (5 mL) containing Krebs solution. The organfluid was gassed with 95% O2 and 50 mL/L CO2 to keepthe pH at 7.40?0.05. Contractile responses to CCK-8(1 ?mol/L) were evaluated in the presence and absenceof NG-nitro-L-arginine (LNNA), an inhibitor of NO synthase(100 ?mol/L), and (p-chloro-D-Phe6-Leu17)-VIP (VIPa,30 ?mol/L), a VIP receptor antagonist.RESULTS: CCK-8 stimulated the phasic activity of the SO.NO synthase inhibition increased the frequency and amplitudeof contractions with a slight increase in developed tension.Pre-incubation with VIPa also attenuated this CCK-8 effect.The combined application of LNNA and VIPa abolishedthe phasic activity of the muscle rings with a marked increasein tension in response to CCK-8.CONCLUSION: VIP and NO together contribute to anincrease in phasic activity of SO.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Sphincter of Oddi CCK VIP NO LNNA
Megjelenés:	World Journal of Gastroenterology. - 11 : 21 (2005), p. 3264-3266. -
További szerzők:	Sári Réka (farmakológus) Németh József (Pécs) Szabolcs Annamária Nagy István Hegyi Péter Jenő (belgyógyász) Lonovics János (Szeged) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
Pályázati támogatás:	3.2.2.-2004-07-0001/3.0 GVOP
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: