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001-es BibID:	BIBFORM046509
035-os BibID:	PMID:9236151
Első szerző:	Szekeres László
Cím:	Delayed cardiac protection against harmful consequences of stress can be induced in experimental atherosclerosis in rabbits / Laszlo Szekeres, Zoltan Szilvassy, Peter Ferdinandy, Istvan Nagy, Sarolta Karcsu, Sándor Csáti
Dátum:	1997
ISSN:	0022-2828
Megjegyzések:	Multiple brief periods of rapid ventricular pacing confer bothshort- and long-term protection on the ischaemic heart. The duration of the short-term protection does notexceed 2 h, whereas the long-term protective effect appears several hours after the inducing insults, with maximalprotection 24?48 h later. Up to now, delayed cardiac protection by preceding ischaemic insults against harmfulconsequences of stress has been produced in the normal, healthy animal only. The purpose of this study was,therefore, to test whether delayed cardiac protection can be induced in experimental atherosclerosis in rabbitsproduced by feeding cholesterol-rich diet over 2 months. Repeated brief periods of rapid ventricular pacing wereused to induce delayed protection of the heart. Moderation of post-pacing right intracavitary ST segment elevationand that of the left ventricular end-diastolic pressure (both produced by ventricular overpacing: 500 beats/minfor 15 min) were found in normal animals as well as in those fed cholesterol-enriched diet. The short-livedprotection induced by a single 'preconditioning' pacing was reproducible only in normal animals. As measuredby means of radioimmunoassay, the protective effect of either short- or long-term protection appeared inparallel with an attenuation of ischaemia-induced increase in cardiac cyclic AMP content, in both normal andatherosclerotic rabbits. An increase in cardiac cyclic GMP content was characteristic of the short- but not longtermprotection. These results suggest that the delayed cardiac protection by preceding multiple brief rapidpacings operates even in experimental atherosclerosis, but the short-term protection induced by a singlepreconditioning stimulus is lost.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Atherosclerosis ischaemia
Megjelenés:	Journal of Molecular and Cellular Cardiology. - 29 :7 (1997), p. 1977-1983. -
További szerzők:	Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Ferdinándy Péter Nagy István Karcsu Sarolta Csáti Sándor
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