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001-es BibID:	BIBFORM048822
Első szerző:	Tsikouras, Panagioti
Cím:	Endometrial cancer : molecular and therapeutic aspects / Panagiotis Tsikouras, Sofia Bouchlariotou, Nikolaos Vrachnis, Alexandros Dafopoulos, Georgios Galazios, Roland Csorba, Georg Friedrich von Tempelhoff
Dátum:	2013
ISSN:	0301-2115
Megjegyzések:	Endometrial cancer (EC) is the most commonly diagnosed gynecologic malignancy. Although early-stage EC is effectively treated surgically, commonly without adjuvant therapy, the treatment of high-risk and advanced disease is more complex. Chemotherapy has evolved into an important modality in high-risk early-stage and advanced-stage disease, and in recurrent EC. Multi-institutional trials are in progress to better define optimal adjuvant treatment for subsets of patients, as well as the role of surgical staging in reducing both overuse and underuse of radiation therapy. Understanding and identifying the molecular biology and genetics of EC are central to the development of novel therapies. A number of molecular and genetic events have been observed in ECs, which have enabled us to have a better understanding of the biology and development of the disease. For example, the PTEN/AKT pathway and its downstream targets and the mTOR pathway have been shown to play an important role in EC pathogenesis. This review summarizes the background of the known molecular alterations, and the management of patients with EC.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Endometrial cancer Management Molecular biology
Megjelenés:	European Journal of Obstetrics Gynecology and Reproductive Biology. - 169 : 1 (2013), p. 1-9. -
További szerzők:	Bouchlariotou, Sofia Vrachnis, Nikolaos Dafopoulos, Alexandros Galazios, Georgios Csorba Roland (1972-) (szülész-nőgyógyász, gyermeknőgyógyász) Tempelhoff, Georg-Friedrich von
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